Evaluation of Protective Effect of Reduced Glutathione on Flutamide-Induced Lipid Peroxidation and Changes in Cholesterol Content Using Common Laboratory Markers

This study was designed with an aim to evaluate the protective effects of reduced glutathione on flutamide-induced lipid peroxidation and also changes in cholesterol content. Blood of male white New Zealand rabbit was used as lipid source for the models. Lipid peroxidation study was performed by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of rabbit blood. An attempt was also made to evaluate the effect of reduced glutathione on flutamide-induced changes in cholesterol content in rabbit blood. In the cholesterol profile total cholesterol and high density lipoprotein cholesterol content of rabbit blood was determined. The data presented in this work demonstrate the lipid peroxidation induction potential of flutamide and the antiperoxidative potential of reduced glutathione on flutamide-induced lipid peroxidation. It was also observed that reduced glutathione had protective effect on flutamide-induced changes in cholesterol content.